No market sells the precious pleasures of healthy sexual relationship. Flaccid penis brings hindrance in the attainment of sexual pleasures fully. Researchers report rapidly increasing incidences of impotence all over the world. To overcome the emerging danger of impotence, attempts were made by a number of pharmaceutical companies to develop drugs which would cure impotence. Pfizer, one of the most competitive drugs producing pharmaceutical company, finally succeeded in manufacturing a magical drug called Viagra highly effective for treating erectile dysfunction. The disease of impotence does not survive the powerful beating of Viagra.
The magical action of Viagra is due to its action on an enzyme named phosphodiesterase. PDE is an enzyme present in the blood vessels of the penis. This enzyme makes possible the breakdown of cGMP into GMP. Potent erection requires high level of cGMP in the blood vessels of the penis. cGMP is formed from GTP by activated guanylyl cyclase. Guanylyl cyclase is activated by Nitric Oxide. Nitric Oxide itself is born in the endothelial cells by the action of an enzyme Nitric Oxide synthase. Nitric Oxide synthase catalyzes the formation of Nitric Oxide from L-arginine. The cGMP is responsible for the dilation of penile vessels. Dilated penile vessels cause the blood to flood out of these vessels to enter in the sinuses of the erectile tissue of the penis. When the sinuses of the erectile tissue get filled with the blood, erection takes place. The erection is feasible only if sexual stimulation is also provided after the intake of Viagra.
Though, the drug is the most prescribed sexual enhancement and also an extremely popular ED treatment, possible side effects the drug might cause are diarrhea, priapism, nasal congestion, cyanotic vision, hearing loss, dizziness, headache and runny nose. In case if any of the side effects keeps residing for more than a couple of hours, immediately quit taking the drug and go to your physician for further advice. 25 mg dosage is to be taken if you are taking the drug for the first time, which could be increased to 50 mg if the previous dosage does not affect erection sufficiently. 100 mg dosage could be achieved if 50 mg dosage fails to provide the maximum effective time of four hours of erection spontaneity. Do not take the drug for more than once on 24 hours time. Do not take nitrate containing drugs, erythromycin or protease inhibitors with the drug. Do not take alcohol with the drug. Do not take the drug with other vasodilators. If you are having liver, heart and kidney problems, do not take their drug as the proper metabolism of the drug be disrupted possible causing drug toxicity. Take the drug half an hour before sexual interaction. Appropriate sexual interaction involving sufficient sexual stimulation is highly advised.
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